Isolated late metastasis from testicular seminoma presenting as a parotid gland mass: case report and review of the literature

  • J. Künzel University Hospital of Erlangen–Nuremberg
  • A. Agaimy University Hospital of Erlangen–Nuremberg
  • S.W. Krause University Hospital of Erlangen–Nuremberg
  • M. Vieth Hospital of Bayreuth
  • C. Alexiou University Hospital of Erlangen–Nuremberg
Keywords: Seminoma, parotid gland, late metastasis

Abstract

Parotid metastases from non–head-and-neck cancers are rare and may represent a diagnostic and therapeutic challenge. A late metastasis to the parotid gland from a seminoma is an unusual manifestation of disease. A 45-year-old man with a history of testicular seminoma 5 years earlier presented with a rapidly progressing parotid mass. Ultrasonography and computed tomography showed a space-occupying lesion at the angle of the right jaw. The mass was infiltrating into the parotid gland and into the parapharyngeal space. A primary parotid neoplasm was suspected, and panendoscopy combined with open biopsy was performed. Histology examination confirmed a seminoma metastatic to the parotid gland, and comparison with the primary tumour showed identical histology. The patient received chemotherapy for recurrent seminoma in accordance with the pei (cisplatin, etoposide, ifosfamide) protocol. After 4 courses of chemotherapy, salvage radical parotidectomy with removal of all suspicious residual tumour tissue was performed. This case illustrates the difficulties that may be encountered in the differential diagnosis of parotid gland masses and underlines the necessity for a detailed clinical history and for strong interdisciplinary collaboration between oncologists and pathologists to correctly diagnose cases with such unusual presentations.

Author Biographies

J. Künzel, University Hospital of Erlangen–Nuremberg
Department of ENT, Head and Neck Surgery
A. Agaimy, University Hospital of Erlangen–Nuremberg
Department of Pathology
S.W. Krause, University Hospital of Erlangen–Nuremberg
Department of Hemato-oncology
M. Vieth, Hospital of Bayreuth
Department of Pathology
C. Alexiou, University Hospital of Erlangen–Nuremberg
Department of ENT, Head and Neck Surgery
How to Cite
Künzel, J., Agaimy, A., Krause, S., Vieth, M., & Alexiou, C. (1). Isolated late metastasis from testicular seminoma presenting as a parotid gland mass: case report and review of the literature. Current Oncology, 20(4), e354-e358. https://doi.org/10.3747/co.20.1489
Section
Case Report