The Role of Vaccine Therapy in Cancer: Biology and Practice

Jeffrey Schlom

Abstract


Vaccines constitute a potential new therapeutic approach for use in a range of human cancers. Unlike other therapeutics, vaccines initiate a dynamic process in the host immune system that can be exploited with subsequent therapies. Indeed, recent preclinical and clinical studies with cancer vaccines have provided evidence that new paradigms should be considered in both clinical trial design and endpoints, and in combination therapies, with this unique therapeutic modality. This article will review and put forth a rationale for these paradigm shifts, with a focus on prostate cancer.

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DOI: http://dx.doi.org/10.3747/co.v14i6.155






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ISSN: 1198-0052 (Print) ISSN: 1718-7729 (Online)