In serum, higher parathyroid hormone but not lower vitamin D is associated with oral squamous cell carcinoma

H. Zhang, H. Lu, C. Shrestha, Y. Feng, Y. Li, J. Peng, Y. Li, Z. Xie

Abstract


Introduction

Vitamin D and calcium are known to regulate differentiation and proliferation of keratinocytes; they might potentially have a role in suppressing carcinogenesis in squamous epithelium. Serum parathyroid hormone (pth) is a sensitive indicator of calcium and vitamin D deficiency, and 25-hydroxyvitamin D [25(OH)D] is an established marker of vitamin D status.

Methods

To determine whether levels of 25(OH)D, calcium, or pth in serum are associated with oral squamous cell carcinoma (oscc), we examined those parameters in serum collected from 70 patients with oscc and from an equal number of matched control subjects.

Results

The results showed that intact pth was significantly higher in serum from oscc patients than in serum from control subjects. However, we observed no significant differences in 25(OH)D or calcium in serum from oscc patients and from control subjects.

Conclusions

We conclude that higher serum pth, but not lower serum vitamin D or calcium, is associated with oscc.


Keywords


Oral squamous cell carcinoma; parathyroid hormone; 25-hydroxyvitamin D; calcium

Full Text:

PDF HTML


DOI: http://dx.doi.org/10.3747/co.22.2259






Copyright © 2019 Multimed Inc.
ISSN: 1198-0052 (Print) ISSN: 1718-7729 (Online)