Secular trends in the survival of patients with laryngeal carcinoma, 1995–2007

  • S.D. MacNeil Department of Otolaryngology-Head and Neck Surgery Western University London Health Sciences Centre
  • K. Liu Institute for Clinical and Evaluative Sciences
  • S.Z. Shariff Institute for Clinical and Evaluative Sciences
  • A. Thind Institute for Clinical and Evaluative Sciences
  • E. Winquist Western University
  • J. Yoo Western University
  • A. Nichols Western University
  • K. Fung Western University
  • S. Hall Institute for Clinical and Evaluative Sciences
  • A.X. Garg Institute for Clinical and Evaluative Sciences
Keywords: laryngeal cancer, population-based, overall survival, laryngectomy-free survival

Abstract

Background

Recent reports suggest a decline over time in the survival of patients newly diagnosed with laryngeal cancer in spite of developments in treatment practices. Our study set out to determine whether the survival of patients with laryngeal cancer in Ontario has changed over time.

Methods

This population-based cohort study of patients diagnosed with laryngeal cancer in the province of Ontario between 1995 and 2007 used data extracted from linked provincial administrative and registry databases. Its main outcomes were overall survival, laryngectomy-free survival, and survival ratio relative to an age- and sex-matched general population.

Results

The 4298 patients newly diagnosed with laryngeal cancer during the period of interest were predominantly men (n = 3615, 84.1%) with glottic cancer (n = 2787, 64.8%); mean age in the group was 66 years (interquartile range: 59–74 years). Patient demographics did not significantly change over time. Overall, 5-year survival was 57.4%; laryngectomy-free survival was 45.4%. Comparing patients from three eras (1995–1998, 1999–2003, 2004–2007) and adjusting for age, sex, and comorbidity status, we observed no differences in overall survival or laryngectomy-free survival over time. The 5-year relative survival ratio for patients with laryngeal cancer compared with an age- and sex-matched group from the general population was 81.1% for glottic cancer and 44.5% for supraglottic cancer.

Conclusions

In patients with a new diagnosis of laryngeal cancer, overall and laryngectomy-free survival have remained unchanged since the mid-1990s. New methods to improve survival and the rate of laryngeal preservation in this patient population are needed.

Published
2015-01-08
How to Cite
MacNeil, S., Liu, K., Shariff, S., Thind, A., Winquist, E., Yoo, J., Nichols, A., Fung, K., Hall, S., & Garg, A. (2015). Secular trends in the survival of patients with laryngeal carcinoma, 1995–2007. Current Oncology, 22(2), e85-e99. https://doi.org/10.3747/co.22.2361
Section
Surgical Oncology