Isolated brain metastases as first site of recurrence in prostate cancer: case report and review of the literature

  • J. Craig The Ottawa Hospital Cancer Centre
  • J. Woulfe The Ottawa Hospital, General Site
  • J. Sinclair The Ottawa Hospital, Civic Site
  • S. Malone The Ottawa Hospital Cancer Centre
Keywords: Prostate cancer, brain metastasis, recurrence

Abstract

Fewer than 2% of patients with metastatic prostate cancer (pca) develop brain metastases. Autopsy series have confirmed the rarity of brain metastases. When present, brain metastases occur in end stage, once the pca is castrate-resistant and spread to other sites is extensive. Here, we present a rare case of a patient with pca who developed a solitary parenchymal brain metastasis as first site of relapse 9 years after radical therapy. The patient underwent craniotomy and excision of the tumour. A second recurrence was also isolated to the brain. In the literature, pca patients with brain metastases have a poor mean survival of 1–7.6 months. The patient in our case report experienced a relatively favourable outcome, surviving 19 months after his initial brain relapse.

Published
2015-09-11
How to Cite
Craig, J., Woulfe, J., Sinclair, J., & Malone, S. (2015). Isolated brain metastases as first site of recurrence in prostate cancer: case report and review of the literature. Current Oncology, 22(6), e493-e497. https://doi.org/10.3747/co.22.2542
Section
Case Report