Relationship between HLA-DRB1 allele polymorphisms and familial aggregations of hepatocellular carcinoma

S. Ma, J. Wu, J. Wu, Y. Wei, L. Zhang, Q. Ning, D. Hu

Abstract


Objective

We explored the relationship between HLA-DRB1 allele polymorphisms and familial aggregation of hepatocellular carcinoma (fhcc).

Methods

Polymerase chain reaction sequence-specific primers were used to determine HLA-DRB1 genotypes for 130 members of families with 2 or more liver cancer patients and for 130 members of families without any diagnosed cancers. The genotype profiles were then compared to explore the relationship between HLA-DRB1 gene polymorphism and fhcc.

Result

Of 11 selected alleles, the frequencies of DRB1*11 and DRB1*12 were significantly lower in the fhcc group than in no-cancer group (p < 0.05; odds ratio: 0.286; 95% confidence interval: 0.091 to 0.901; and odds ratio: 0.493; 95% confidence interval: 0.292 to 0.893). Differences in the frequencies of the other 9 alleles were not statistically significant in the two groups (p > 0.05).

Conclusions

Our research suggests that if genetic factors play a role in fhcc, the deficiency in the DRB1*11 and DRB1*12 alleles might be the risk factor at work in Guangxi Zhuang Autonomous Region, P.R.C. 


Keywords


HLA-DRB1 alleles; polymorphisms; hepatocellular carcinoma; familial aggregation; pcr-ssp

Full Text:

PDF HTML


DOI: http://dx.doi.org/10.3747/co.23.2839






Copyright © 2019 Multimed Inc.
ISSN: 1198-0052 (Print) ISSN: 1718-7729 (Online)