The Brain Metastases Symptom Checklist as a novel tool for symptom measurement in patients with brain metastases undergoing whole-brain radiotherapy

  • D. Rodin University of Toronto
  • B. Banihashemi Lakeridge Health Corporation
  • L. Wang Princess Margaret Cancer Centre
  • A. Lau Princess Margaret Cancer Centre
  • S. Harris Princess Margaret Cancer Centre
  • W. Levin University of Toronto; Princess Margaret Cancer Centre
  • R. Dinniwell University of Toronto; Princess Margaret Cancer Centre
  • B.A. Millar University of Toronto; Princess Margaret Cancer Centre
  • C. Chung University of Toronto; Princess Margaret Cancer Centre
  • N. Laperriere University of Toronto; Princess Margaret Cancer Centre
  • A. Bezjak University of Toronto; Princess Margaret Cancer Centre
  • R.K.S. Wong University of Toronto; Princess Margaret Cancer Centre
Keywords: Brain metastases, symptoms, patient-reported outcomes, whole-brain radiotherapy

Abstract

Purpose

We evaluated the feasibility, reliability, and validity of the Brain Metastases Symptom Checklist (BMSC), a novel self-report measure of common symptoms experienced by patients with brain metastases.

Methods

Patients with first-presentation symptomatic brain metastases (n = 137) referred for whole-brain radiotherapy (WBRT) completed the BMSC at time points before and after treatment. Their caregivers (n = 48) provided proxy ratings twice on the day of consultation to assess reliability, and at week 4 after WBRT to assess responsiveness to change. Correlations with 4 other validated assessment tools were evaluated.

Results

The symptoms reported on the BMSC were largely mild to moderate, with tiredness (71%) and difficulties with balance (61%) reported most commonly at baseline. Test–retest reliability for individual symptoms had a median intraclass correlation of 0.59 (range: 0.23–0.85). Caregiver proxy and patient responses had a median intraclass correlation of 0.52. Correlation of absolute scores on the BMSC and other symptom assessment tools was low, but consistency in the direction of symptom change was observed. At week 4, change in symptoms was variable, with improvements in weight gain and sleep of 42% and 41% respectively, and worsening of tiredness and drowsiness of 62% and 59% respectively.

Conclusions

The BMSC captures a wide range of symptoms experienced by patients with brain metastases, and it is sensitive to change. It demonstrated adequate test–retest reliability and face validity in terms of its responsiveness to change. Future research is needed to determine whether modifications to the BMSC itself or correlation with more symptom-specific measures will enhance validity.

 

Author Biographies

D. Rodin, University of Toronto
Department of Radiation Oncology
B. Banihashemi, Lakeridge Health Corporation
Department of Radiation Oncology
L. Wang, Princess Margaret Cancer Centre
Department of Biostatistics
A. Lau, Princess Margaret Cancer Centre
Department of Biostatistics
S. Harris, Princess Margaret Cancer Centre
Palliative Radiation Oncology Program
W. Levin, University of Toronto; Princess Margaret Cancer Centre
Department of Radiation Oncology; Radiation Medicine Program
R. Dinniwell, University of Toronto; Princess Margaret Cancer Centre
Department of Radiation Oncology; Radiation Medicine Program
B.A. Millar, University of Toronto; Princess Margaret Cancer Centre
Department of Radiation Oncology; Radiation Medicine Program
C. Chung, University of Toronto; Princess Margaret Cancer Centre
Department of Radiation Oncology; Radiation Medicine Program
N. Laperriere, University of Toronto; Princess Margaret Cancer Centre
Department of Radiation Oncology; Radiation Medicine Program
A. Bezjak, University of Toronto; Princess Margaret Cancer Centre
Department of Radiation Oncology; Radiation Medicine Program
R.K.S. Wong, University of Toronto; Princess Margaret Cancer Centre
Department of Radiation Oncology; Radiation Medicine Program
Published
2016-06-13
How to Cite
Rodin, D., Banihashemi, B., Wang, L., Lau, A., Harris, S., Levin, W., Dinniwell, R., Millar, B., Chung, C., Laperriere, N., Bezjak, A., & Wong, R. (2016). The Brain Metastases Symptom Checklist as a novel tool for symptom measurement in patients with brain metastases undergoing whole-brain radiotherapy. Current Oncology, 23(3), e239-e247. https://doi.org/10.3747/co.23.2936
Section
Palliative Care