Nasopharyngeal non-intestinal-type adenocarcinoma: a case report and updated review of the literature

  • C. Jain University of Ottawa
  • L. Caulley University of Ottawa; The Ottawa Hospital
  • K.I. Macdonald University of Ottawa; The Ottawa Hospital
  • B. Purgina The Ottawa Hospital; University of Ottawa
  • C.K. Lai The Ottawa Hospital; University of Ottawa
  • B. Esche The Ottawa Hospital; University of Ottawa
  • S. Johnson-Obaseki University of Ottawa; The Ottawa Hospital
Keywords: Non-intestinal adenocarcinoma, intestinal adenocarcinoma, sinonasal cavity, nasopharynx, disease classifications

Abstract

Background

Non-intestinal-type adenocarcinoma is a malignancy traditionally found in the sinonasal cavity. To our knowledge, this case is the first reported of this rare condition originating in the nasopharynx.

Case Presentation

A 67-year-old woman with nasopharyngeal non-intestinal-type adenocarcinoma, with an accompanying parapharyngeal mass received primary radiation treatment for both lesions. Her tumour subsequently persisted, with a concomitant conversion in pathology from a low- to a high-grade malignancy.

Results

Non-intestinal-type and intestinal-type adenocarcinomas of the nasopharynx are extremely rare tumours and do not appear in the World Health Organization classification system. We review the pathophysiologic features of these malignancies and propose modifications to the current classification system.

Conclusions

Non-intestinal-type adenocarcinoma should be included in the differential diagnosis of nasopharyngeal masses. In our experience, this tumour in this location showed a partial response to primary radiation but later converted from a low- to a high-grade adenocarcinoma.

Author Biographies

C. Jain, University of Ottawa
Faculty of Medicine
L. Caulley, University of Ottawa; The Ottawa Hospital

Department of Otolaryngology–Head and Neck Surgery

K.I. Macdonald, University of Ottawa; The Ottawa Hospital
Department of Otolaryngology–Head and Neck Surgery
B. Purgina, The Ottawa Hospital; University of Ottawa

Department of Pathology and Laboratory Medicine

C.K. Lai, The Ottawa Hospital; University of Ottawa

Department of Pathology and Laboratory Medicine

B. Esche, The Ottawa Hospital; University of Ottawa

Department of Radiation Oncology

S. Johnson-Obaseki, University of Ottawa; The Ottawa Hospital

Department of Otolaryngology–Head and Neck Surgery; 

Published
2017-02-28
How to Cite
Jain, C., Caulley, L., Macdonald, K., Purgina, B., Lai, C., Esche, B., & Johnson-Obaseki, S. (2017). Nasopharyngeal non-intestinal-type adenocarcinoma: a case report and updated review of the literature. Current Oncology, 24(1), e55-e60. https://doi.org/10.3747/co.24.3299
Section
Case Report