Diagnostic value of epidermal growth factor, cancer antigen 125, and cancer antigen 15-3 in bronchoalveolar lavage fluid of lung cancer

  • S. Sun Ningbo University
  • Z. Chen Ningbo First Hospital
  • C. Cao Ningbo First Hospital
  • B. Wu Guangdong Medicine College
  • B. Wang Ningbo University
  • Y. Yu Ningbo University
  • Z. Chen Ningbo University
  • Z. Hu Cixi People’s Hospital
  • Z. Deng Ningbo University
Keywords: Lung cancer, bronchoalveolar lavage fluid, epidermal growth factor, cancer antigen 125, cancer antigen 15-3

Abstract

Aim

In the present study, we assessed the diagnostic value of epidermal growth factor (egf) and cancer antigens 125 (ca125) and 15-3 (ca15-3) in bronchoalveolar lavage fluid (balf) of lung cancer from 79 enrolled patients with suspected lung cancer.

Methods

All patients underwent fibrescopic examination, during which balf samples were collected. Levels of egf, ca125, and ca15-3 were determined in balf using commercially available test kits.

Results

The results showed that levels of egf in balf were significantly higher in patients with lung cancer than in patients with benign diseases (p < 0.01); no significant differences for ca125 (p = 0.67) or ca15-3 (p = 0.43) in balf were observed between the lung cancer patients and the non-cancer control subjects. With a cut-off value of 27.22 pg/mL, egf showed a sensitivity of 63.6% and a specificity of 65.7% in predicting the malignant nature of pulmonary disease.

Conclusions

The study findings suggest that levels of egf are significantly increased in balf from patients with lung cancer than in balf from patients with benign disease. Detection of the level of egf in balf is proposed as a non-invasive test to identify patients at high risk for lung cancer.

Author Biographies

S. Sun, Ningbo University
Department of Respiratory Medicine, The Affiliated Hospital of Medical College,
Z. Chen, Ningbo First Hospital
Department of Emergency Medicine
C. Cao, Ningbo First Hospital
Departmentof Respiratory Medicine
B. Wu, Guangdong Medicine College
Department of Respiratory and Critical Care Medicine, Affiliated Hospital, Institute of Respiratory Diseases
B. Wang, Ningbo University
Department of Respiratory Medicine, The Affiliated Hospital of Medical College
Y. Yu, Ningbo University
Department of Respiratory Medicine, The Affiliated Hospital of Medical College
Z. Chen, Ningbo University
Department of Respiratory Medicine, The Affiliated Hospital of Medical College
Z. Hu, Cixi People’s Hospital
Department of Respiratory Medicine
Z. Deng, Ningbo University
Department of Respiratory Medicine, The Affiliated Hospital of Medical College
Published
2017-06-28
How to Cite
Sun, S., Chen, Z., Cao, C., Wu, B., Wang, B., Yu, Y., Chen, Z., Hu, Z., & Deng, Z. (2017). Diagnostic value of epidermal growth factor, cancer antigen 125, and cancer antigen 15-3 in bronchoalveolar lavage fluid of lung cancer. Current Oncology, 24(3), e180-e184. https://doi.org/10.3747/co.24.3348
Section
Biomarkers in Oncology