Molecular progression in unusual recurrent non-pediatric intracranial clear cell meningioma

  • B. Domingo-Arrué Universitat de València
  • R. Gil-Benso Universitat de València
  • J. Megías Universitat de València
  • L. Navarro University of Valencia
  • T. San-Miguel Universitat de València
  • L. Muñoz-Hidalgo Clinic Hospital of Valencia
  • C. López-Ginés Universitat de València
  • M. Cerdá-Nicolás Universitat de València; Clinic Hospital of Valencia
Keywords: Clear cell meningioma, recurrence, intracranial disease, non-pediatric disease, genetics, NF2, tumour suppressor genes, molecular progression

Abstract

We report a case of a recurrent clear cell meningioma (ccm) in the frontal lobe of the brain of a 67-year-old man. The patient developed three recurrences: at 3, 10, and 12 years after his initial surgery. Histopathology observations revealed a grade 2 ccm with positivity for vimentin and epithelial membrane antigen. Expression of E-cadherin was positive only in the primary tumour and in the first available recurrence. Fluorescence in situ hybridization analyses demonstrated 1p and 14q deletions within the last recurrence. Multiplex ligation-dependent probe amplification studies revealed a heterozygous partial NF2 gene deletion, which progressed to total loss in the last recurrence. The last recurrence showed homozygous deletions in CDKN2A and CDKN2B. The RASSF1 gene was hypermethylated during tumour evolution.

In this report, we show the genetic alterations of a primary ccm and its recurrences to elucidate their relationships with the changes involved in the progression of this rare neoplasm.

Author Biographies

B. Domingo-Arrué, Universitat de València
Department of Pathology
R. Gil-Benso, Universitat de València
Department of Pathology
J. Megías, Universitat de València
Department of Pathology
L. Navarro, University of Valencia
Department of Pathology
T. San-Miguel, Universitat de València
Department of Pathology
L. Muñoz-Hidalgo, Clinic Hospital of Valencia
incliva
C. López-Ginés, Universitat de València
Department of Pathology
M. Cerdá-Nicolás, Universitat de València; Clinic Hospital of Valencia
Department of Pathology; incliva
Published
2017-06-28
How to Cite
Domingo-Arrué, B., Gil-Benso, R., Megías, J., Navarro, L., San-Miguel, T., Muñoz-Hidalgo, L., López-Ginés, C., & Cerdá-Nicolás, M. (2017). Molecular progression in unusual recurrent non-pediatric intracranial clear cell meningioma. Current Oncology, 24(3), e244-e250. https://doi.org/10.3747/co.24.3509
Section
Case Report