Intravenous vitamin C in the supportive care of cancer patients: a review and rational approach

E. Klimant, H. Wright, D. Rubin, D. Seely, M. Markman


This article reviews intravenous vitamin C (IV C) in cancer care and offers a rational approach to enable medical oncologists and integrative practitioners to safely provide IV C combined with oral vitamin C to patients. The use of IV C is a safe supportive intervention to decrease inflammation in the patient and to improve symptoms related to antioxidant deficiency, disease processes, and side effects of standard cancer treatments. A proposed rationale, together with relevant clinical safety considerations for the application of IV C in oncologic supportive care, is provided.


Vitamin C deficiency; intravenous vitamin C; ascorbate; supportive care; quality of life

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ISSN: 1198-0052 (Print) ISSN: 1718-7729 (Online)