Updates from the 2017 American Society of Hematology annual meeting: practice-changing studies in untreated chronic lymphocytic leukemia

  • C. Owen University of Calgary and Foothills Medical Centre
  • C. Toze British Columbia; University of British Columbia; Vancouver General Hospital
  • A. Christofides IMPACT Medicom Inc
Keywords: Untreated disease, first-line treatments, treatment-naïve patients, chronic lymphocytic leukemia

Abstract

The 2017 annual meeting of the American Society of Hematology took place 9–12 December in Atlanta, Georgia. At the meeting, the oral presentations included results from key studies on the first-line treatment of chronic lymphocytic leukemia. A series of phase ii studies focusing on the efficacy and safety of novel treatment strategies were especially notable. One concerned the health-related quality of life results from the gibb study, which had examined the combination of obinutuzumab and bendamustine. A second evaluated the venetoclax–ibrutinib regimen in patients with high-risk disease. The third assessed the combination of ibrutinib, fludarabine, cyclophosphamide, and obinutuzumab in patients with mutated immunoglobulin heavy-chain variable region genes. The fourth examined the combination of ibrutinib, fludarabine, cyclophosphamide, and rituximab in younger patients. And the final study evaluated obinutuzumab–ibrutinib followed by a minimal residual disease strategy in fit patients. Our meeting report describes the foregoing studies and presents interviews with investigators and commentaries by Canadian hematologists about the potential effects on Canadian practice.


Author Biographies

C. Owen, University of Calgary and Foothills Medical Centre
Division of Hematology and Hematological Malignancies
C. Toze, British Columbia; University of British Columbia; Vancouver General Hospital
Leukemia/Bone Marrow Transplant Program; Division of Hematology
Published
2018-02-28
How to Cite
Owen, C., Toze, C., & Christofides, A. (2018). Updates from the 2017 American Society of Hematology annual meeting: practice-changing studies in untreated chronic lymphocytic leukemia. Current Oncology, 25(1), 91-103. https://doi.org/10.3747/co.25.4005
Section
Meeting Report