Updates from the 2017 American Society of Hematology annual meeting: practice-changing studies in relapsed and refractory mantle cell lymphoma

  • C. Owen University of Calgary and Foothills Medical Centre
  • J. Kuruvilla University of Toronto, and Princess Margaret Cancer Centre
  • A. Christofides IMPACT Medicom Inc.
Keywords: Relapsed disease, refractory disease, mantle cell lymphoma

Abstract

The 2017 annual meeting of the American Society of Hematology took place 9–12 December in Atlanta, Georgia. At the meeting, results from key studies in the treatment of relapsed and refractory mantle cell lymphoma were presented. Of those studies, oral presentations focused on the efficacy and safety of therapy with Bruton tyrosine kinase (btk) inhibitors. One study presented pooled data from three trials using ibrutinib, with a median follow-up of 3.5 years. A second phase ii study presented data on the efficacy and safety of acalabrutinib, a highly selective btk inhibitor with minimal off-target activity. The final study presented early phase ib data on the efficacy and safety of zanubrutinib, a novel, highly selective btk inhibitor, in patients with non-Hodgkin lymphoma. Our meeting report describes the foregoing studies and presents interviews with investigators and commentaries by Canadian hematologists about potential effects on Canadian practice.

Author Biographies

C. Owen, University of Calgary and Foothills Medical Centre
Division of Hematology and Hematological Malignancies
J. Kuruvilla, University of Toronto, and Princess Margaret Cancer Centre
Department of Medicine
Published
2018-02-28
How to Cite
Owen, C., Kuruvilla, J., & Christofides, A. (2018). Updates from the 2017 American Society of Hematology annual meeting: practice-changing studies in relapsed and refractory mantle cell lymphoma. Current Oncology, 25(1), 83-90. https://doi.org/10.3747/co.25.4006
Section
Meeting Report