Does the presence of emphysema increase the risk of radiation pneumonitis in lung cancer patients?

  • G. Kasymjanova Sir Mortimer B. Davis Jewish General Hospital
  • R. T. Jagoe Sir Mortimer B. Davis Jewish General Hospital
  • C. Pepe Sir Mortimer B. Davis Jewish General Hospital
  • L. Sakr Sir Mortimer B. Davis Jewish General Hospital
  • V. Cohen Sir Mortimer B. Davis Jewish General Hospital
  • D. Small Sir Mortimer B. Davis Jewish General Hospital
  • T. M. Muanza Sir Mortimer B. Davis Jewish General Hospital
  • J. S. Agulnik Sir Mortimer B. Davis Jewish General Hospital
Keywords: Lung cancer, emphysema, radiation pneumonitis

Abstract

Introduction Radiotherapy (rt) plays an important role in the treatment of lung cancer. One of the most common comorbidities in patients with lung cancer is pulmonary emphysema. The literature offers conflicting data about whether emphysema increases the occurrence and severity of radiation pneumonitis (rp). As a result, whether high doses of rt (with curative intent) should be avoided in patients with emphysema is still unclear.

Objective We measured the documented incidence of rp in patients with and without emphysema who received curative radiation treatment.

Methods This retrospective cohort study considered patients in the lung cancer clinical database of the Peter Brojde Lung Cancer Centre. Data from the database has been used previously for research studies, including a recent publication about emphysema grading, based on the percentage of lung occupied by emphysema on computed tomography (ct) imaging.

Results Using previously published methods, chest ct imaging for 498 patients with lung cancer was scored for the presence of emphysema. The analysis considered 114 patients who received at least 30 Gy radiation. Of those 114 patients, 64 (56%) had emphysema, with approximately 23% having severe or very severe disease. The incidence of rp was 34.4% in patients with emphysema (n = 22) and 32.0% in patients with no emphysema (n = 16, p = 0.48). No difference in the incidence of rp was evident between patients with various grades of emphysema (p = 0.96). Similarly, no difference in the incidence of rp was evident between the two treatment protocols—that is, definitive rt 17 (37%) and combined chemotherapy–rt 21 (31%, p = 0.5).

Conclusions In our cohort, the presence of emphysema on chest ct imaging was not associated with an increased risk of rp. That finding suggests that patients with lung cancer and emphysema should be offered rt when clinically indicated. However, further prospective studies will be needed for confirmation.

Author Biographies

G. Kasymjanova, Sir Mortimer B. Davis Jewish General Hospital
Peter Brojde Lung Cancer Centre
R. T. Jagoe, Sir Mortimer B. Davis Jewish General Hospital
Peter Brojde Lung Cancer Centre
C. Pepe, Sir Mortimer B. Davis Jewish General Hospital
Peter Brojde Lung Cancer Centre
L. Sakr, Sir Mortimer B. Davis Jewish General Hospital
Peter Brojde Lung Cancer Centre
V. Cohen, Sir Mortimer B. Davis Jewish General Hospital
Peter Brojde Lung Cancer Centre
D. Small, Sir Mortimer B. Davis Jewish General Hospital
Peter Brojde Lung Cancer Centre
T. M. Muanza, Sir Mortimer B. Davis Jewish General Hospital
Peter Brojde Lung Cancer Centre, Radiation Oncology, Segal
Cancer Centre
J. S. Agulnik, Sir Mortimer B. Davis Jewish General Hospital
Peter Brojde Lung Cancer Centre
Published
2018-12-20
How to Cite
Kasymjanova, G., Jagoe, R. T., Pepe, C., Sakr, L., Cohen, V., Small, D., Muanza, T. M., & Agulnik, J. S. (2018). Does the presence of emphysema increase the risk of radiation pneumonitis in lung cancer patients?. Current Oncology, 25(6). https://doi.org/10.3747/co.25.4093
Section
Perspectives in Oncology