FOLFIRINOX in patients with peritoneal carcinomatosis from pancreatic adenocarcinoma: a retrospective study

E. Bonnet, C. Mastier, A. Lardy-Cléaud, P. Rochefort, M. Sarabi, P. Guibert, A. Cattey-Javouhey, F. Desseigne, C. de La Fouchardière

Abstract


Background Peritoneal carcinomatosis (PCM) in metastatic pancreatic ductal adenocarcinomas (mPDAC) is frequently encountered in day-to-day practice, but rarely addressed in the literature. The objective of the present study was to describe the management and outcome of patients diagnosed with PCM.

Methods Data for all consecutive patients with mpdac treated in our centre between 1 January 2014 and 31 August 2015 were analyzed retrospectively. Computed tomography imaging was centrally reviewed by a dedicated radiologist to determine the date of pcm diagnosis.

Results The analysis included 48 patients. Median age in the group was 61 years, and 41 patients had an Eastern Cooperative Oncology Group performance status (ECOG PS) of 0–1. All patients presented with pcm either synchronously (group 1) or metachronously (group 2). Those groups differed significantly by baseline ecog ps and neutrophil-tolymphocyte ratio (nlr), with ecog ps being poorer and nlr being higher in group 1. In addition to PCM, the main sites of metastasis were liver (62.5%) and lungs (31.3%). First-line chemotherapy in 36 patients (75%) was FOLFIRINOX (fluorouracil–irinotecan–leucovorin–oxaliplatin). The median overall survival for the entire population was 10.81 months [95% confidence interval (ci): 7.16 months to 14.16 months]; it was 13.17 months (95% ci: 5.9 months to 15.4 months) for patients treated with folfirinox. Median overall survival was 7.13 months (95% ci: 4.24 months to 10.41 months) for patients in group 1 and 14.34 months (95% ci: 9.79 months to 19.91 months) for patients in group 2, p = 0.1296.

Conclusions Compared with other metastatic sites, synchronous pcm seems to be a poor prognostic factor. It could be more frequently associated with a poor ECOG PS and a NLR greater than 5 in this group of patients. In patients with mPDAC and PCM, either synchronous or metachronous, FOLFIRINOX remains an efficient regimen.


Keywords


Prognosis; metastatic sites; pancreatic cancer; peritoneal carcinomatosis

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DOI: http://dx.doi.org/10.3747/co.26.4903






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ISSN: 1198-0052 (Print) ISSN: 1718-7729 (Online)