Diagnosis, monitoring, and management of adverse events from immune checkpoint inhibitor therapy

  • O.F. Khan Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB http://orcid.org/0000-0003-4424-5360
  • J. Monzon Department of Medical Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB
Keywords: Immune checkpoint inhibitors, adverse events, PD-L1, PD-1, CTLA-4, immunotherapy

Abstract

Immune checkpoint inhibitor therapy (ICIT) is now standard of care for a variety of cancers in both the metastatic and adjuvant settings. As a result, it is imperative to understand the timing, epidemiology, monitoring, diagnosis, and management of immune related adverse events (irAEs) associated with ICIT. This article reviews specific irAEs by organ system, consolidating recommendations from multiple guidelines and incorporating data from case reports to highlight additional evolving therapeutic options for patients. Managing these adverse events requires early recognition, early intervention, and education of both patients and the multidisciplinary health care team. Given the durable responses observed with ICIT, and the irreversible nature associated with some of these irAEs, further research into management of the sequelae of ICIT is required.


Published
2019-03-02
How to Cite
Khan, O., & Monzon, J. (2019). Diagnosis, monitoring, and management of adverse events from immune checkpoint inhibitor therapy. Current Oncology, 27(S2). https://doi.org/10.3747/co.27.5111