Severe Raynaud syndrome induced by adjuvant interferon alfa in metastatic melanoma

H. Husein-ElAhmed, J.L. Callejas-Rubio, R. Ortega Del Olmo, R. Rios-Fernandez, N. Ortego-Centeno

Abstract


Melanoma is the most lethal form of skin malignancy because of its aggressive behaviour. In advanced dis­ease, interferon alfa can be used as adjuvant therapy. However, this therapy is not free of side effects. We present a case of severe Raynaud syndrome and digi­tal necrosis induced by interferon alfa in a patient with melanoma. Pathogenic mechanisms are discussed.


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DOI: http://dx.doi.org/10.3747/co.v17i4.519






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ISSN: 1198-0052 (Print) ISSN: 1718-7729 (Online)