Severe Raynaud syndrome induced by adjuvant interferon alfa in metastatic melanoma

H. Husein-ElAhmed, J.L. Callejas-Rubio, R. Ortega Del Olmo, R. Rios-Fernandez, N. Ortego-Centeno


Melanoma is the most lethal form of skin malignancy because of its aggressive behaviour. In advanced dis­ease, interferon alfa can be used as adjuvant therapy. However, this therapy is not free of side effects. We present a case of severe Raynaud syndrome and digi­tal necrosis induced by interferon alfa in a patient with melanoma. Pathogenic mechanisms are discussed.

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ISSN: 1198-0052 (Print) ISSN: 1718-7729 (Online)