Ductal carcinoma in situ in a 25-year-old man presenting with apparent unilateral gynecomastia

  • C.J. Coroneos The University of Western Ontario
  • C. Hamm Windsor Regional Cancer Centre

Abstract

Ductal carcinoma in situ (DCIS) in a young man is rarely reported. Our patient, a 25-year-old man, pre­sented with apparent symptomatic unilateral gyneco­mastia. He has a strong history of cancer on both the maternal and paternal sides of his family, including breast and lung (maternal) and melanoma, colon, and pancreatic (paternal). His mother tested negative for BRCA1 and BRCA2. There is no information on paternal genetic testing.

The patient was treated with left subcutaneous mastectomy. Upon histologic review of the sample, concurrent gynecomastia and DCIS were discovered. To date, only 4 cases of gynecomastia and DCIS have been described in younger male patients. Because only 30%-50% of patients with DCIS eventually develop invasive cancer in the subsequent 10-20 years, DCIS prevalence in the general population may be higher than predicted. This case underscores the importance of family history in any patient presenting with a breast mass. Patients must be made aware of the risk, however small it may be, and physicians must remain cautious of cancer in young men with gynecomastia.

Author Biographies

C.J. Coroneos, The University of Western Ontario

MD Candidate, Class of 2010, The University of Western Ontario

Permanent Contact Info:

1204 Highgate Pl

Mississauga ON L4W3H4

Tel: 905 282 0328

Fax: 519 255 8675 (ATTN: Dr. C. Hamm)

C. Hamm, Windsor Regional Cancer Centre
Medical Oncologist, Director of Research, Windsor Regional Cancer Centre Adjunct Professor, The University of Western Ontario & The University of Windsor 2200 Kildare Road Windsor, ON, Canada N8W 2X3 Tel: (519) 253 5253 Fax: (519) 255 8675
How to Cite
Coroneos, C., & Hamm, C. (1). Ductal carcinoma in situ in a 25-year-old man presenting with apparent unilateral gynecomastia. Current Oncology, 17(4), 133-137. https://doi.org/10.3747/co.v17i4.525
Section
Case Report