Cyclophosphamide–bortezomib– dexamethasone compared with bortezomib–dexamethasone in transplantation-eligible patients with newly diagnosed multiple myeloma

  • A. Figueiredo The Ottawa Hospital
  • H. Atkins The Ottawa Hospital
  • R. Mallick The OttawaHospital Research Institute
  • N. Kekre The Ottawa Hospital
  • A. Kew The Ottawa Hospital
  • A. McCurdy The Ottawa Hospital
Keywords: myeloma, bortezomib, toxicity, CyBorD

Abstract

Introduction Cyclophosphamide–bortezomib–dexamethasone (CyBorD) is considered a standard induction regimen for transplant-eligible patients with newly diagnosed multiple myeloma (mm). It has not been prospectively compared with bortezomib–dexamethasone (Bor-Dex). We aimed to compare the efficacy of CyBorD and Bor-Dex induction in transplant-eligible patients.

Methods In a retrospective observational study at a single tertiary centre, all patients with transplant-eligible mm who received induction with CyBorD or Bor-Dex between March 2008 and April 2016 were enrolled. Progression-free survival (pfs), response, and stem-cell collection for a first autologous stem-cell transplantation (ahsct) were compared.

Results Of 155 patients enrolled, 78 (50.3%) had received CyBorD, and 77 (49.7%), Bor-Dex. The patients in the Bor-Dex cohort were younger than those in the CyBorD cohort (median: 57 years vs. 62 years; p = 0.0002) and more likely to have had treatment held, reduced, or discontinued (26% vs. 14.5%, p = 0.11). The stem-cell mobilization regimen for both cohorts was predominantly cyclophosphamide and granulocyte colony–stimulating factor (gcsf). Plerixafor was used more often for the CyBorD cohort (p = 0.009), and more collection failures occurred in the CyBorD cohort (p = 0.08). In patients receiving Bor-Dex, more cells were collected (9.9×106 cells/kg vs. 7.7×106cells/kg, p = 0.007). At day +100, a very good partial response or better was achieved in 75% of the CyBorD cohort and in 73% of the Bor-Dex cohort (p = 0.77). Median pfs was 3.2 years in the Bor-Dex cohort and 3.7 years in the CyBorD cohort (p = 0.56).

Conclusions Overall efficacy was similar in our patients receiving CyBorD and Bor-Dex. After ahsct, no difference in depth of response or pfs was observed. Cyclophosphamide–gcsf seems to increase collection failures and hospitalizations in patients receiving CyBorD. Prospective studies are required to examine that relationship.


Author Biographies

A. Figueiredo, The Ottawa Hospital

Division of Hematology

H. Atkins, The Ottawa Hospital

Division of Hematology

R. Mallick, The OttawaHospital Research Institute

School of Epidemiology, Public Health and Preventive Medicine

N. Kekre, The Ottawa Hospital

Division of Hematology

A. Kew, The Ottawa Hospital

Division of Hematology

A. McCurdy, The Ottawa Hospital

Division of Hematology

Published
2019-10-21
How to Cite
Figueiredo, A., Atkins, H., Mallick, R., Kekre, N., Kew, A., & McCurdy, A. (2019). Cyclophosphamide–bortezomib– dexamethasone compared with bortezomib–dexamethasone in transplantation-eligible patients with newly diagnosed multiple myeloma. Current Oncology, 27(2). https://doi.org/10.3747/co.27.5385
Section
Medical Oncology