Low-grade spindle-cell ameloblastic carcinoma: report of an unusual case with immunohistochemical findings and review of the literature

  • C. Jindal MM College of Dental Sciences & Research, Mullana-133203, Haryana, India.
  • S. Palaskar MM College of Dental Sciences & Research, Mullana-133203, Haryana, India.
  • H. Kaur MM College of Dental Sciences & Research, Mullana-133203, Haryana, India.
  • M. Shankari MM College of Dental Sciences & Research, Mullana-133203, Haryana, India.

Abstract

Spindle-cell differentiation in ameloblastic carcinoma is a rare event. Although reported by many authors, it was first described as a separate entity in 1999 by Slater under the heading "low-grade spindlecell ameloblastic carcinoma." Here, we report a case of low-grade spindle-cell ameloblastic carcinoma arising in pre-existing unicystic ameloblastoma.

The patient, a 60-year-old Indian woman, had a large irregular swelling in the left mandibular region. Histologically, the lesion was composed of a large cystic cavity with an ameloblastomatous lining and areas showing spindle-cell proliferation. The spindle cells showed hyperchromatism, nuclear pleomorphism, and scattered mitotic figures. To our knowledge, 6 cases of spindle-cell ameloblastic carcinoma have been published to date, and this case appears to be the first reporting malignant transformation with spindle-cell differentiation in unicystic ameloblastoma.

Author Biographies

C. Jindal, MM College of Dental Sciences & Research, Mullana-133203, Haryana, India.

BDS MDS final year

Deptt. of Oral & Maxillofacial Pathology

 

S. Palaskar, MM College of Dental Sciences & Research, Mullana-133203, Haryana, India.

MDS

HOD, Deptt. of Oral & Maxillofacial Pathology

H. Kaur, MM College of Dental Sciences & Research, Mullana-133203, Haryana, India.

MDS

Deptt. of Oral & Maxillofacial Pathology

M. Shankari, MM College of Dental Sciences & Research, Mullana-133203, Haryana, India.

MDS

Deptt. of Oral & Maxillofacial Pathology

How to Cite
Jindal, C., Palaskar, S., Kaur, H., & Shankari, M. (1). Low-grade spindle-cell ameloblastic carcinoma: report of an unusual case with immunohistochemical findings and review of the literature. Current Oncology, 17(5), 52-57. https://doi.org/10.3747/co.v17i5.580
Section
Case Report