Primary central nervous system T-cell lymphoma in AIDS patients: case report and literature review

S. Latta, Z.W. Myint, B. Jallad, T. Hamdi, M.N. Alhosaini, D.V. Kumar, F. Kheir


According to the published data, most primary central nervous system lymphomas (PCNSLs) are B-cell lymphomas; primary T-cell lymphomas are rare. In a search of the MEDLINE database, we found only 6 cases of primary T-cell PCNSL. Here, we present the case of a 43-year-old man with AIDS, not on highly active antiretroviral therapy, who presented with focal neurologic symptoms and was found on magnetic resonance imaging to have multiple brain lesions. A biopsy showed T-cell lymphoma, and the patient was subsequently treated with whole-brain radiation, to marked clinical response. Reported cases from the literature of primary T-cell PCNSL in AIDS patients are summarized in this review.

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ISSN: 1198-0052 (Print) ISSN: 1718-7729 (Online)