A pan-Canadian prospective study of young women with breast cancer: the rationale and protocol design for the RUBY study

  • M.L. Quan University of Calgary
  • I.A. Olivotto Cumming School of Medicine, University of Calgary
  • N.N. Baxter Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto
  • C.M. Friedenreich CancerControl Alberta, Alberta Health Services, University of Calgary
  • K. Metcalfe Lawrence S. Bloomberg Faculty of Nursing
  • E. Warner Sunnybrook Odette Cancer Centre
  • K. MacLennan Li Ka Shing Knowledge Institute of St. Michael’s Hospital, University of Toronto
  • J.E. Stephen Alberta Health Services
  • M. Akbari University of Toronto, Dalla Lana School of Public Health, University of Toronto
  • D. Howell CancerControl Alberta, Alberta Health Services
  • S. Narod University of Toronto
  • Jay Engel
  • Louise Provencher
  • Ari Meguerditchian
  • Kelly Dabbs
  • Mylene Ward
  • Lucy Helyer
  • Jean Francois Boileau
  • Nicole Hodgson
  • Gary Groot
  • Tony Gomes
  • Muriel Brackstone
  • Mai-Kim Gervais
  • Andre Robidoux
  • Bryan Wells
  • Christopher Cox
  • Nancy Down
  • David McCready
  • Rebecca Warburton
  • Banks Brie
  • Baliski Christopher
  • Rene Hanrahan
  • Ralph George
  • Frances Wright
  • Matthew Holmes
  • Marianna Kapala
  • Darren Biberdorf
  • Priya Chopra
  • Pamela Hebbard
  • Angel Arnaout
  • Tulin Cil
  • Poole Alex
  • Antoine Bouchard-Fortier
  • RUBY site investigators
Keywords: young onset breast cancer, prospective cohort, pan-Canadian, knowledge translation, patient reported outcomes, biorepository

Abstract

Introduction The understanding of the biology and epidemiology of, and the optimal therapeutic strategies for, breast cancer (bca) in younger women is limited. We present the rationale, design, and initial recruitment of Reducing the Burden of Breast Cancer in Young Women (ruby), a unique national prospective cohort study designed to examine the diagnosis, treatment, quality of life, and outcomes from the time of diagnosis for young women with bca.

Methods Over a 4-year period at 33 sites across Canada, the ruby study will use a local and virtual recruitment model to enrol 1200 women with bca who are 40 years of age or younger at the time of diagnosis, before initiation of any treatment. At a minimum, comprehensive patient, tumour, and treatment data will be collected to evaluate recurrence and survival. Patients may opt to complete patient-reported questionnaires, to provide blood and tumour samples, and to be contacted for future research, forming the core dataset from which 4 subprojects evaluating genetics, lifestyle factors, fertility, and local management or delivery of care will be performed.

Summary The ruby study will be the most comprehensive repository of data, biospecimens, and patient-reported outcomes ever collected with respect to young women with bca from the time of diagnosis, enabling research unique to that population now and into the future. This research model could be used for other oncology settings in Canada.


Author Biographies

M.L. Quan, University of Calgary

Department of Surgery, Cumming School of Medicine, Department of Oncology, Cumming School of Medicine, Department of Community Health Sciences

I.A. Olivotto, Cumming School of Medicine, University of Calgary

Department of Oncology

N.N. Baxter, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto

Department of Surgery, Women’s College Hospital

C.M. Friedenreich, CancerControl Alberta, Alberta Health Services, University of Calgary

Department of Oncology, Cumming School of Medicine, Department of Community Health Sciences, Department of Cancer Epidemiology and Prevention Research

E. Warner, Sunnybrook Odette Cancer Centre

Division of Medical Oncology

K. MacLennan, Li Ka Shing Knowledge Institute of St. Michael’s Hospital, University of Toronto

Applied Health Research Centre (ahrc)

J.E. Stephen, Alberta Health Services

Clinical Neurosciences Program

M. Akbari, University of Toronto, Dalla Lana School of Public Health, University of Toronto

Women’s College Hospital

D. Howell, CancerControl Alberta, Alberta Health Services

Department of Cancer Epidemiology and Prevention Research

S. Narod, University of Toronto

Women’s College Hospital, Dalla Lana School of Public Health

Published
2020-05-29
How to Cite
Quan, M., Olivotto, I., Baxter, N., Friedenreich, C., Metcalfe, K., Warner, E., MacLennan, K., Stephen, J., Akbari, M., Howell, D., Narod, S., Engel, J., Provencher, L., Meguerditchian, A., Dabbs, K., Ward, M., Helyer, L., Boileau, J. F., Hodgson, N., Groot, G., Gomes, T., Brackstone, M., Gervais, M.-K., Robidoux, A., Wells, B., Cox, C., Down, N., McCready, D., Warburton, R., Brie, B., Christopher, B., Hanrahan, R., George, R., Wright, F., Holmes, M., Kapala, M., Biberdorf, D., Chopra, P., Hebbard, P., Arnaout, A., Cil, T., Alex, P., Bouchard-Fortier, A., & RUBY site investigators. (2020). A pan-Canadian prospective study of young women with breast cancer: the rationale and protocol design for the RUBY study. Current Oncology, 27(5). https://doi.org/10.3747/co.27.6751
Section
Commentary