Multimodal approaches to high-risk prostate cancer

A. Koupparis, M.E. Gleave

Abstract


Widespread use of testing for prostate-specific antigen (PSA) has led to a migration in the stage and grade of prostate cancer (PCa), with most men presenting with localized disease. However, 20%-35% of patients still present with high-risk disease (PSA > 20 ng/mL, biopsy Gleason score 8 10, or clinical stage T3). Despite advances in various treatment modalities, patients with high-risk disease have a significant chance of recurrence and death after surgery, often because of the presence of early occult metastasis at time of diagnosis. The optimal management of high-risk PCa remains controversial. The present article aims to discuss the traditional approaches and the more recent evolution toward multimodal therapies.


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DOI: http://dx.doi.org/10.3747/co.v17i0.677






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ISSN: 1198-0052 (Print) ISSN: 1718-7729 (Online)