Occult cause of paraneoplastic acanthosis nigricans in a patient with known breast dcis: case and review

B. D. Jakubovic, H. F. Sawires, D. N. Adam


Paraneoplastic acanthosis nigricans (PAN) is an infrequently encountered cutaneous manifestation of internal malignancy. Here, we describe a case of PAN in the setting of a known breast ductal carcinoma in situ, which, to our knowledge, had not been described in association with PAN. As a result, thorough investigation was undertaken to search for another concurrent neoplasm that would better explain the development of PAN. In so doing, we identified a coexisting metastatic cholangiocarcinoma. We thus conclude that when pan is observed in an uncommon association with a known malignancy, further investigation should be undertaken to explore whether a more likely occult culprit exists.

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DOI: http://dx.doi.org/10.3747/co.19.997

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ISSN: 1198-0052 (Print) ISSN: 1718-7729 (Online)